Industrial Ecology Analysis of the Potential for an Eastern Nebraska Industrial Symbiosis Network (ENISN): A Comparative Study

The area of Eastern Nebraska north of Omaha, including the municipality of Blair is host to a collection of unique companies and industries. These industries, driven by the agricultural and urban economy of the area, as well as the geographic proximity to each other, make it an advantageous area to study the potential for a network where individual entities utilize the concept of industrial symbiosis. This potential network is referred to as the Eastern Nebraska Industrial Symbiosis Network (ENISN). Industrial symbiosis, a sub-set of industrial ecology, engages separate industries in a collaborative and collective approach, concerning itself with the flow of materials and energy, water, and/or by-products between each other. The outcome of industrial symbiosis is advantageous to not only the companies, but to the environment as well. The incorporation of ecological economic principles are at the core of industrial symbiosis. A circular-economy invites a more sustainable approach where efficient allocation of resources and a philosophy of an end to growth, drive this unique economy that differs from the traditional neoclassical style. This study compares the potential of an ENISN with the existing Kalundborg Symbiosis in Kalundborg, Denmark, a long established example of industrial ecology and the use of an eco-industrial network where the by-product of one enterprise is used as a resource by another enterprise, in a closed cycle. Industrial symbiosis is a collaboration where public and private enterprises buy and sell residual products, resulting in mutual economic and environmental benefits. The results of this study indicate the ENISN study site has the potential for an industrial symbiosis site. The analysis of material flows and inductive themes derived from interviews with potential partners revealed the presence of collaboration and environmental stewardship. The results of the study suggest that the human capital exists to make an ENISN; however, the impetus to take on the challenging ontological barriers remains to be seen. Advisor: Mark E. Burbac

A Robust and Universal Metaproteomics Workflow for Research Studies and Routine Diagnostics Within 24 h Using Phenol Extraction, FASP Digest, and the MetaProteomeAnalyzer

The investigation of microbial proteins by mass spectrometry (metaproteomics) is a key technology for simultaneously assessing the taxonomic composition and the functionality of microbial communities in medical, environmental, and biotechnological applications. We present an improved metaproteomics workflow using an updated sample preparation and a new version of the MetaProteomeAnalyzer software for data analysis. High resolution by multidimensional separation (GeLC, MudPIT) was sacrificed to aim at fast analysis of a broad range of different samples in less than 24 h. The improved workflow generated at least two times as many protein identifications than our previous workflow, and a drastic increase of taxonomic and functional annotations. Improvements of all aspects of the workflow, particularly the speed, are first steps toward potential routine clinical diagnostics (i.e., fecal samples) and analysis of technical and environmental samples. The MetaProteomeAnalyzer is provided to the scientific community as a central remote server solution at www.mpa.ovgu.de.Peer Reviewe

The role of linguistic experience in the hemispheric processing of lexical tone

This is the publisher's version, made available with the permission of the publisher.This study investigated hemispheric lateralization of Mandarin tone. Four groups of listeners were examined: native Mandarin listeners, English–Mandarin bilinguals, Norwegian listeners with experience with Norwegian tone, and American listeners with no tone experience. Tone pairs were dichotically presented and listeners identified which tone they heard in each ear. For the Mandarin listeners, 57% of the total errors occurred in the left ear, indicating a right-ear (left-hemisphere) advantage. The English– Mandarin bilinguals exhibited nativelike patterns, with 56% left-ear errors. However, no ear advantage was found for the Norwegian or American listeners (48 and 47% left-ear errors, respectively). Results indicate left-hemisphere dominance of Mandarin tone by native and proficient bilingual listeners, whereas nonnative listeners show no evidence of lateralization, regardless of their familiarity with lexical tone

Plain-to-clear speech video conversion for enhanced intelligibility

Clearly articulated speech, relative to plain-style speech, has been shown to improve intelligibility. We examine if visible speech cues in video only can be systematically modified to enhance clear-speech visual features and improve intelligibility. We extract clear-speech visual features of English words varying in vowels produced by multiple male and female talkers. Via a frame-by-frame image-warping based video generation method with a controllable parameter (displacement factor), we apply the extracted clear-speech visual features to videos of plain speech to synthesize clear speech videos. We evaluate the generated videos using a robust, state of the art AI Lip Reader as well as human intelligibility testing. The contributions of this study are: (1) we successfully extract relevant visual cues for video modifications across speech styles, and have achieved enhanced intelligibility for AI; (2) this work suggests that universal talker-independent clear-speech features may be utilized to modify any talker’s visual speech style; (3) we introduce “displacement factor” as a way of systematically scaling the magnitude of displacement modifications between speech styles; and (4) the high definition generated videos make them ideal candidates for human-centric intelligibility and perceptual training studies

Impact of Age and Body Site on Adult Female Skin Surface pH

Background: pH is known as an important parameter in epidermal barrier function and homeostasis. Aim: The impact of age and body site on skin surface pH (pH(SS)) of women was evaluated in vivo. Methods: Time domain dual lifetime referencing with luminescent sensor foils was used for pH(SS) measurements. pH(SS) was measured on the forehead, the temple, and the volar forearm of adult females (n = 97, 52.87 +/- 18.58 years, 20-97 years). Every single measurement contained 2,500 pH values due to the luminescence imaging technique used. Results: pH(SS) slightly increases with age on all three investigated body sites. There are no significant differences in pH(SS) between the three investigated body sites. Conclusion: Adult pH(SS) on the forehead, the temple and the volar forearm increases slightly with age. This knowledge is crucial for adapting medical skin care products. Copyright (C) 2012 S. Karger AG, Base

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

OBJECTIVE: To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment. METHODS: To illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks. RESULTS: As of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female. CONCLUSION: Collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD